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1

Characteristics of the Novel Potassium-Competitive Acid Blocker Vonoprazan Fumarate (TAK-438)

Otake, Kazuyoshi, Sakurai, Yuuichi, Nishida, Haruyuki, Fukui, Hideo, Tagawa, Yoshihiko, Yamasaki, Hitomi, Karashima, Masatoshi, Otsuka, Keiichi, Inatomi, Nobuhiro

Journal:

Advances in Therapy

Year:

2016

Language:

english

File:

PDF, 3.12 MB

english, 2016

2

Discovery of a Novel Pyrrole Derivative 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine Fumarate (TAK-438) as a Potassium-Competitive Acid Blocker (P-CAB)

Arikawa, Yasuyoshi, Nishida, Haruyuki, Kurasawa, Osamu, Hasuoka, Atsushi, Hirase, Keizo, Inatomi, Nobuhiro, Hori, Yasunobu, Matsukawa, Jun, Imanishi, Akio, Kondo, Mitsuyo

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.26 MB

english, 2012

3

A comparative study on the modes of action of TAK-438, a novel potassium-competitive acid blocker, and lansoprazole in primary cultured rabbit gastric glands

Jun Matsukawa, Yasunobu Hori, Haruyuki Nishida, Masahiro Kajino, Nobuhiro Inatomi

Journal:

Biochemical Pharmacology

Year:

2011

Language:

english

File:

PDF, 213 KB

english, 2011

4

Novel 3-phenylpiperidine-4-carboxamides as highly potent and orally long-acting neurokinin-1 receptor antagonists with reduced CYP3A induction

Junya Shirai, Hideyuki Sugiyama, Shinji Morimoto, Hironobu Maezaki, Yasuharu Yamamoto, Satoshi Okanishi, Izumi Kamo, Shiho Matsumoto, Keiko Ishigami, Nobuhiro Inatomi, Akio Imanishi, Makiko Kawamoto,

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 919 KB

english, 2012

5

EM574, an erythromycin derivative, improves delayed gastric emptying of semi-solid meals in conscious dogs

Fumihiko Sako, Shogo Marui, Nobuhiro Inatomi, Zen Itoh, Satoshi Ōmura

Journal:

European Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 325 KB

english, 2000

6

Corrigendum to: EM574, an erythromycin derivative, improves delayed gastric emptying of semi-solid meals in conscious dogs [Eur. J. Pharmacol. 395 (2000) 165–172.]

Fumihiko Sato, Shogo Marui, Nobuhiro Inatomi, Zen Itoh, Satoshi Ōmura

Journal:

European Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 40 KB

english, 2000

7

Role of peroxisomal fatty acid beta-oxidation in ethanol metabolism

Nobuhiro Inatomi, Shinzo Kato, Daisuke Ito, Charles S. Lieber

Journal:

Biochemical and Biophysical Research Communications

Year:

1989

Language:

english

File:

PDF, 428 KB

english, 1989

8

Gastric mucosal protection by spizofurone

Nobuhiro Inatomi, Hiroshi Satoh, Ikuko Inada, Takeo Hirata, Hideaki Nagaya, Yoshitaka Maki

Journal:

European Journal of Pharmacology

Year:

1985

Language:

english

File:

PDF, 528 KB

english, 1985

9

Spizofurone (AG-629) increases gastric mucosal blood flow in dogs: A possible mechanism of its anti-ulcer effect

Nobuhiro Inatomi, Hiroshi Satoh, Hideaki Nagaya, Yoshitaka Maki

Journal:

European Journal of Pharmacology

Year:

1985

Language:

english

File:

PDF, 559 KB

english, 1985

10

Spizofurone, a new anti-ulcer agent, increases alkaline secretion in isolated bullfrog duodenal mucosa

Ikuko Inada, Hiroshi Satoh, Nobuhiro Inatomi, Hideaki Nagaya, Yoshitaka Maki

Journal:

European Journal of Pharmacology

Year:

1986

Language:

english

File:

PDF, 488 KB

english, 1986

11

Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers

Haruyuki Nishida, Atsushi Hasuoka, Yasuyoshi Arikawa, Osamu Kurasawa, Keizo Hirase, Nobuhiro Inatomi, Yasunobu Hori, Fumihiko Sato, Naoki Tarui, Akio Imanishi, Mitsuyo Kondo, Terufumi Takagi, Masahiro

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.05 MB

english, 2012

12

Effects of the enantiomers of lansoprazole (AG-1749) on (H+ + K+)-ATPase activity in canine gastric microsomes and acid formation in isolated canine parietal cells

Hideaki Nagaya, Nobuhiro Inatomi, Akira Nohara, Hiroshi Satoh

Journal:

Biochemical Pharmacology

Year:

1991

Language:

english

File:

PDF, 366 KB

english, 1991

13

Intracellular cyclic AMP level and intestinal smooth muscle relaxation

Nobuhiro Inatomi, Issei Takayanagi, Masaatsu Uchida, Keijiro Takagi

Journal:

European Journal of Pharmacology

Year:

1974

Language:

english

File:

PDF, 285 KB

english, 1974

14

Indomethacin-induced changes in canine gastric mucosal haemodynamics and haemoglobin oxygenation, and the effects of topical anti-ulcer agents

NOBUHIRO INATOMI, NOBUHIRO SATO, HIROSHI SATOH, YOSHITAKA MAKI, NOBUTO NAKAMURA, TAKENOBU KAMADA

Journal:

Journal of Gastroenterology and Hepatology

Year:

1986

Language:

english

File:

PDF, 571 KB

english, 1986

15

Stimulatory mechanism of EM523-induced contractions in postprandial stomach of conscious dogs

Yoshihiro Shiba, Akiyoshi Mizumoto, Nobuhiro Inatomi, Norihiro Haga, Osamu Yamamoto, Zen Itoh

Journal:

Gastroenterology

Year:

1995

Language:

english

File:

PDF, 988 KB

english, 1995

16

Clinical and biologic characteristics of CD7+ acute myeloid leukemia: Our experience and literature review

Takashi Shimamoto, Junko H. Ohyashiki, Kazuma Ohyashiki, Ken Kawakubo, Yuka Inatomi, Hiromi Fujieda, Shinpei Nakazawa, Nobuhiro Kimura, Jun Miyauchi, Keisuke Toyama

Journal:

Cancer Genetics and Cytogenetics

Year:

1994

Language:

english

File:

PDF, 805 KB

english, 1994

17

EM574, an erythromycin derivative, is a motilin receptor agonist in the rabbit

Fumihiko Sato, Masahiro Sekiguchi, Shogo Marui, Nobuhiro Inatomi, Akio Shino, Zen Itoh, Satoshi Ōmura

Journal:

European Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 458 KB

english, 1997

18

1045 A Neutral Intragastric pH is Required for Eradication of Helicobacter pylori by Amoxicillin

Elizabeth A. Marcus, George Sachs, Nobuhiro Inatomi, David R. Scott

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 104 KB

english, 2012

19

Macrolide Antibiotics || Mode of Action of Macrolides with Motilin Agonistic Activity—Motilides

Inatomi, Nobuhiro

Year:

2003

Language:

english

File:

PDF, 2.29 MB

english, 2003

20

W1091 Effects of Tak-438, a Novel Potassium-Competitive Acid Blocker (P-Cab), on Gastric Acid Secretion in Animals

Hori, Yasunobu, Matsukawa, Jun, Tsukimi, Yasuhiro, Nishida, Haruyuki, Arikawa, Yasuyoshi, Hirase, Keizo, Imanishi, Akio, Kajino, Masahiro, Inatomi, Nobuhiro

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 54 KB

english, 2010

21

Antinociceptive properties of NK1 receptor antagonists on colorectal distension in rabbits

Inatomi, Nobuhiro, Okano, Shiho, Ikeura, Yoshinori, Natsugari, Hideaki

Journal:

Gastroenterology

Year:

2001

Language:

english

File:

PDF, 187 KB

english, 2001

22

Macrolides with gastrointestinal motor stimulating activity

Omura, Satoshi, Tsuzuki, Kazuo, Sunazuka, Toshiaki, Marui, Shogo, Toyoda, Hajime, Inatomi, Nobuhiro, Itoh, Zen

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 340 KB

english, 1987

23

Synthetic studies of five-membered heteroaromatic derivatives as potassium-competitive acid blockers (P-CABs)

Arikawa, Yasuyoshi, Hasuoka, Atsushi, Nishida, Haruyuki, Hirase, Keizo, Inatomi, Nobuhiro, Takagi, Terufumi, Tarui, Naoki, Kawamoto, Makiko, Imanishi, Akio, Itoh, Fumio, Kajino, Masahiro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 344 KB

english, 2015

24

Mo1146 Localization of a Novel Potassium Competitive Acid Blocker, Vonoprazan, in the Rat Gastric Mucosa: A Radiographic Study

Matsukawa, Jun, Kogame, Akifumi, Tagawa, Yoshihiko, Inatomi, Nobuhiro

Journal:

Gastroenterology

Year:

2015

Language:

english

File:

PDF, 656 KB

english, 2015

25

Radiographic Localization Study of a Novel Potassium-Competitive Acid Blocker, Vonoprazan, in the Rat Gastric Mucosa

Matsukawa, Jun, Kogame, Akifumi, Tagawa, Yoshihiko, Inatomi, Nobuhiro

Journal:

Digestive Diseases and Sciences

Year:

2016

Language:

english

File:

PDF, 9.86 MB

english, 2016

26

Potassium-competitive acid blockers: Advanced therapeutic option for acid-related diseases

Inatomi, Nobuhiro, Matsukawa, Jun, Sakurai, Yuuichi, Otake, Kazuyoshi

Journal:

Pharmacology & Therapeutics

Year:

2016

Language:

english

File:

PDF, 627 KB

english, 2016

27

Role of xanthine oxidase in ethanol-induced lipid peroxidation in rats

Kato, Shinzo, Kawase, Tateo, Alderman, Jeffrey, Inatomi, Nobuhiro, Lieber, Charles S.

Journal:

Gastroenterology

Year:

1990

Language:

english

File:

PDF, 1.12 MB

english, 1990

28

Motilides, macrolides with gastrointestinal motor stimulating activity. II. Quaternary N-substituted derivatives of 8,9-anhydroerythromycin A 6,9-hemiacetal and 9,9-dihydroerythromycin A 6,9-epoxide.

SUNAZUKA, Toshiaki, TSUZUKI, Kazuo, MARUI, Shogo, TOYODA, Hajime, OMURA, Satoshi, INATOMI, Nobuhiro, ITOH, Zen

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1989

File:

PDF, 1.14 MB

1989

29

Microbial Conversion of EM574 and EM523, Gastrointestinal Motor Stimulating Agents.

FUNABASHI, YASUNORI, HAKODA, SEIJI, INATOMI, NOBUHIRO, KOYAMAN, KATSUO, TANIDA, SEIICHI, HARADA, SETSUO, ITOH, ZEN, OMURA, SATOSHI

Journal:

The Journal of Antibiotics

Year:

1996

Language:

english

File:

PDF, 775 KB

english, 1996

30

Bioactive Metabolites of EM574 and EM523, Erythromycin Derivatives Having Strong Gastrointestinal Motor Stimulating Activity.

FUNABASHI, YASUNORI, MAESHIBA, YOSHIHIRO, INATOMI, NOBUHIRO, TANAYAMA, SHIGEHARU, HARADA, SETSUO, ITOH, ZEN, OMURA, SATOSHI

Journal:

The Journal of Antibiotics

Year:

1996

Language:

english

File:

PDF, 612 KB

english, 1996

31

Molecular Modeling, Design, Synthesis, and Biological Activity of 1H-Pyrrolo[2,3-c]pyridine-7-amine Derivatives as Potassium-Competitive Acid Blockers

Arikawa, Yasuyoshi, Hasuoka, Atsushi, Hirase, Keizo, Inatomi, Nobuhiro, Sato, Fumihiko, Hori, Yasunobu, Takagi, Terufumi, Tarui, Naoki, Kawamoto, Makiko, Kajino, Masahiro

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2014

Language:

english

File:

PDF, 1.80 MB

english, 2014

32

Effects of lansoprazole on indomethacin-induced gastric bleeding and mucosal lesions in rats.

MURAKAMI, Izumi, ASANO, Shoichi, YUKISHIGE, Koichi, NAGAYA, Hideaki, SATOH, Hiroshi, INATOMI, Nobuhiro

Journal:

Folia Pharmacologica Japonica

Year:

1996

File:

PDF, 1.15 MB

1996

33

Effects of intravenous lansoprazole on acute gastric mucosal lesions and acid secretion.

INATOMI, Nobuhiro, MURAKAMI, Izumi, ASANO, Shoichi, INADA, Ikuko, SATOH, Hiroshi

Journal:

Folia Pharmacologica Japonica

Year:

1996

File:

PDF, 1.51 MB

1996

34

Pharmacological and clinical profiles of a novel potassium-competitive acid blocker, vonoprazan fumarate (Takecab® 10 mg and 20 mg)

Matsukawa, Jun, Inatomi, Nobuhiro, Otake, Kazuyoshi

Journal:

Folia Pharmacologica Japonica

Year:

2015

File:

PDF, 710 KB

2015

35

ANTI-OXYTOCIN ACTIONS OF PAPAVERINE, ASPAMINOL AND ISOPRENALINE ON THE RAT UTERUS AND INTRACELLULAR CYCLIC ADENOSINE 3, 5-MONOPHOSPHATE LEVEL

URUNO, Tsutomu, TAKAYANAGI, Issei, INATOMI, Nobuhiro, TAKAGI, Keijiro

Journal:

The Japanese Journal of Pharmacology

Year:

1973

Language:

english

File:

PDF, 103 KB

english, 1973

36

EFFECTS OF ANTI-ULCER AGENTS ON THERMAL-CORTISONE-INDUCED ULCERS IN RATS

INATOMI, Nobuhiro, ISHIHARA, Yasunobu, OKABE, Susumu

Journal:

The Japanese Journal of Pharmacology

Year:

1979

Language:

english

File:

PDF, 226 KB

english, 1979

37

Effects of a Proton Pump Inhibitor, AG-1749 (Lansoprazole), on Reflux Esophagitis and Experimental Ulcers in Rats.

Inatomi, Nobuhiro, Nagaya, Hideaki, Takami, Kenji, Shino, Akio, Satoh, Hiroshi

Journal:

The Japanese Journal of Pharmacology

Year:

1991

Language:

english

File:

PDF, 869 KB

english, 1991

38

Effects of TAK-480, a Novel Tachykinin NK2^|^ndash;Receptor Antagonist, on Visceral Hypersensitivity in Rabbits and Ricinoleic Acid^|^ndash;Induced Defecation in Guinea Pigs

Tanaka, Takahiro, Tanaka, Akiko, Nakamura, Akihiro, Matsushita, Kozo, Imanishi, Akio, Matsumoto-Okano, Shiho, Inatomi, Nobuhiro, Miura, Kasei, Toyoda, Masao, Mizojiri, Gaku, Tsukimi, Yasuhiro

Journal:

Journal of Pharmacological Sciences

Year:

2012

Language:

english

File:

PDF, 471 KB

english, 2012

39

The syntheses and .BETA.-adrenoceptor activities of N-substituted 2-amino-5,6-dihydroxy-1,2,3,4-tetrahydro-1-naphthalenols.

ITOH, KATSUMI, MOTOHASHI, MICHIO, KURIKI, HISASHI, SUGIHARA, HIROSADA, INATOMI, NOBUHIRO, NISHIKAWA, MASAO, OKA, YOSHIKAZU

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1977

File:

PDF, 1.39 MB

1977

40

Motilides, macrolides with gastrointestinal motor stimulating activity. I. O-substituted and tertiary N-substituted derivatives of 8,9-anhydroerythromycin A 6,9-hemiacetal.

TSUZUKI, Kazuo, SUNAZUKA, Toshiaki, MARUI, Shogo, TOYODA, Hajime, OMURA, Satoshi, INATOMI, Nobuhiro, ITOH, Zen

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1989

File:

PDF, 1.83 MB

1989

41

Pharmacological and clinical profile of lansoprazole (Takepron®IV injection 30 mg)

Inatomi, Nobuhiro, Nitta, Katsuyuki, Sakurai, Yuichi

Journal:

Folia Pharmacologica Japonica

Year:

2008

File:

PDF, 504 KB

2008

42

INTRACELLULAR CYCLIC ADENOSINE 3', 5'-MONOPHOSPHATE AND RELAXING EFFECTS OF ISOPRENALINE AND PAPAVERINE ON SMOOTH MUSCLE OF INTESTINE

TAKAYANAGI, Issei, UCHIDA, Masaatsu, INATOMI, Nobuhiro, TOMIYAMA, Akira, TAKAGI, Keijiro

Journal:

The Japanese Journal of Pharmacology

Year:

1972

Language:

english

File:

PDF, 154 KB

english, 1972

43

ANTIPHOSPHODIESTERASE ACTIVITY AND NONSPECIFIC SMOOTH MUSCLE RELAXATION TESTED ON INTESTINAL SMOOTH MUSCLES

INATOMI, Nobuhiro, TAKAYANAGI, Issei, TAKAGI, Keijiro

Journal:

The Japanese Journal of Pharmacology

Year:

1975

Language:

english

File:

PDF, 263 KB

english, 1975

44

Effect of prostaglandins on mucosal blood flow and aspirin-induced damage in the canine stomach.

INATOMI, Nobuhiro, MAKI, Yoshitaka

Journal:

The Japanese Journal of Pharmacology

Year:

1983

Language:

english

File:

PDF, 481 KB

english, 1983

45

Differences in the Antisecretory Actions of the Proton Pump Inhibitor AG-1749 (Lansoprazole) and the Histamine H2-Receptor Antagonist Famotidine in Rats and Dogs.

Nagaya, Hideaki, Inatomi, Nobuhiro, Satoh, Hiroshi

Journal:

The Japanese Journal of Pharmacology

Year:

1991

Language:

english

File:

PDF, 644 KB

english, 1991

46

Role of Endogenous Basic Fibroblast Growth Factor in the Healing of Gastric Ulcers in Rats.

Satoh, Hiroshi, Shino, Akio, Sato, Fumihiko, Asano, Shoichi, Murakami, Izumi, Inatomi, Nobuhiro, Nagaya, Hideaki, Kato, Koichi, Szabo, Sandor, Folkman, Judah

Journal:

The Japanese Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 1.40 MB

english, 1997

47

Comparison of the Motor-Stimulating Action of EM523, an Erythromycin Derivative, and Prostaglandin F2.ALPHA. in Conscious Dogs.

Inatomi, Nobuhiro, Satoh, Takashi, Satoh, Hiroshi, Itoh, Zen, Omura, Satoshi

Journal:

The Japanese Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 541 KB

english, 1993

48

Vagus-Dependent and Vagus-Independent Mechanisms of Action of the Erythromycin Derivative EM574 and Motilin in Dogs.

Inatomi, Nobuhiro, Sato, Fumihiko, Marui, Shogo, Itoh, Zen, Omura, Satoshi

Journal:

The Japanese Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 656 KB

english, 1996

49

Establishment and Validation of a Rabbit Model for In Vivo Pharmacodynamic Screening of Tachykinin NK2 Antagonists

Tanaka, Takahiro, Matsumoto-Okano, Shiho, Inatomi, Nobuhiro, Fujioka, Yasushi, Kamiguchi, Hidenori, Yamaguchi, Masashi, Imanishi, Akio, Kawamoto, Makiko, Miura, Kasei, Nishikawa, Yoichi, Tsukimi, Yasu

Journal:

Journal of Pharmacological Sciences

Year:

2012

Language:

english

File:

PDF, 368 KB

english, 2012

50

Novelty Stress Increases Fecal Pellet Output in Mongolian Gerbils: Effects of Several Drugs

Okano, Shiho, Nagaya, Hideaki, Inatomi, Nobuhiro

Journal:

Journal of Pharmacological Sciences

Year:

2005

Language:

english

File:

PDF, 494 KB

english, 2005

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